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Thyroglobulin Antigen ELIZA / REF: EIA-3377

Thyroglobulin Antigen ELIZA / REF: EIA-3377

Thyroglobulin Antigen ELIZA / REF: EIA-3377

Description:

Thyroglobulin Antigen

Thyroglobulin is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of thyroglobulin in human serum. The assay is intended for in vitro use only as an aid in the determination of various thyroid diseases such as thyroiditis and hyperthyroidism. In the United States, this kit is intended for Research Use Only.

Thyroglobulin (hTG) is a multiple glycosylated, water soluble iodoprotein. The molecular weight of approx. 660.000 Dalton is shared by two identical subunits. Thyroglobulin is synthesized in the thyrocytes of the thyroid gland and secreted into the lumen of the thyroid follicles. Iodination of the proteins tyrosyl residues lead to the precursors of the thyroid hormones T3 and T4. Finally the free T3 and free T4 are liberated into circulation, together with small amounts of thyroglobulin. Like for T3 and T4, synthesis and secretion of thyroglobulin is controlled by TSH and TRH. Suppressive medication using the thyroid hormones also leads to lower thyroglobulin serum concentration. Elevated thyroglobulin serum concentrations have been reported in various thyroid diseases, such as: – hyperthyroidism – non-toxic goiter – thyroiditis – differentiated thyroid carcinoma

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